Travel from Pisa to Rome and discover this Lazio city of 2.300.000 inhabitants. The distance from Pisa to Rome is 424 kilometers; with Wanderio you can compare the available trains, buses, and flights to get from Pisa to Rome, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a flight from Pisa to Rome, you’ll get to your destination in about 1 hour on average; flight ticket prices start from 52 €. Going from Pisa to Rome by train instead? Prices for your ticket start from 23 € and the train journey takes about 2 hours on average.